منابع مشابه
Innate immunity includes defensins
COMMENTARY We would like to comment on the comprehensive review of Karantanos and Gazouli in Annals of Gastroenterology [1] about genetics and innate immunity in inflammatory bowel disease (IBD). The authors appreciate the important role of innate immune sensing and the production of antimicrobial peptides in maintaining the integrity of the mucosal barrier. Pertinent studies on the subject are...
متن کاملDefensins and Sepsis
Sepsis is a leading cause of mortality and morbidity in the critical illness. Multiple immune inflammatory processes take part in the pathogenesis of sepsis. Defensins are endogenous antimicrobial peptides with three disulphide bonds created by six cysteine residues. Besides the intrinsic microbicidal properties, defensins are active players which modulate both innate and adaptive immunity agai...
متن کاملDefensins in viral infections.
Defensins are antimicrobial peptides important to innate host defense. In addition to their direct antimicrobial effect, defensins modulate immune responses. Increasing evidence indicates that defensins exhibit complex functions by positively or negatively modulating infections of both enveloped and non-enveloped viruses. The effects of defensins on viral infections appear to be specific to the...
متن کاملDefensins neutralize anthrax toxin
Anthrax causes an infectious disease mostly in pigs, cattle, horses, sheep and goats. The disease is rare in humans and occurs primarily in regions with intensive farming. The lethal toxin (LeTx) composed of the lethal factor (LF) and the protective antigen (PA) is mostly responsible for the high mortality of anthrax. Although Bacillus anthracis can be treated by antibiotics, this chemotherapy ...
متن کاملBasic insight on plant defensins
Defensins are small cysteine-rich peptides with antimicrobial activity. Plant defensins have a characteristic threedimensional folding pattern that is stabilized by eight disulfide-linked cysteines. This pattern is very similar to defense peptides of mammals and insects, suggesting an ancient and conserved origin. Functionally, these proteins exhibit a diverse array of biological activities, al...
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ژورنال
عنوان ژورنال: Veterinary Immunology and Immunopathology
سال: 2008
ISSN: 0165-2427
DOI: 10.1016/j.vetimm.2007.12.006